Heparin neutralization after Cardiac surgery: The dose may be repeated at 0.5 mg per 100 units of heparin if the patient continues to bleed or if the aPTT remains elevated.

The maximum single dose should not exceed 50 mg.1 mg of protamine neutralizes about 100 units of heparin.Protamine sulfate dose to neutralize Heparin (off-label): 25 - 50 mg is administered slowly intravenously followed by the rest of the dose over 8 - 16 hours.Administer 1 - 1.5 mg protamine per 100 units heparin.Protamine sulfate dose in Heparin overdosage following SubQ injection (off-label dosing):

The dose of Protamine to Neutralize 100 units of Heparinġ - 1.5 mg per 100 units of heparin administeredĠ.5 - 0.75 mg of protamine per 100 units of heparin Protamine sulfate dose for intravenous Heparin Overdosage: Treatment with protamine sulfate depends on the time elapsed since the last dose as per the following table:

Heparin intravenous administration has a short half-life.

Protamin sulfate dose in Adults Protamin sulfate dose in patients with heparin overdosage (following intravenous administration):

Intracranial hemorrhage associated with the use of enoxaparin or other LMWH or unfractionated heparin.

It may also be used as an off-label medicine in the following situations:

It is administered as an intravenous infusion, however, rapid administration of the drug should be avoided as it may cause life-threatening hypotension and anaphylactic reactions. It may also be used to partially reverse the effects of LMWH (low molecular weight heparin) and fondaparinux. Protamine sulfate is used as an antidote in patients with heparin overdose. Vaccines & immunoglobulins Vitamins Gout treatment Featured Video Consultation

Antidote for heparin overdose